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alcohol drinking blush blush is a warning to warn
you blush a drink to people? Because a friend laughed at, intended to increase the combat strength by it? Rumor smash advise you not to work ah. Blushing is a sign, you're not drinking at all, hijacking will only make your own deep woods da.
rumors: about one-third of the East Asian drink will blush, this symptom is called Asian Flush, will increase the risk of fatal esophageal cancer risk. Blush responders are drinking because of its metabolic enzyme alcohol ALDH2 gene is defective, can not be metabolized into acetaldehyde, acetate, resulting in a large number of toxic accumulation of acetaldehyde in the body, causing blood vessels to dilate, causing flushing reaction. ~ ~ ~ Do not try to be brave,
red sole shoes, and after the drink less or not drink, strong risk of esophageal cancer can not be it!
truth: in referring to rumors, soon after drinking the body's skin to turn red face, the phenomenon does exist. As often happens in the Asian body, so was only known as the But many people think that it is allergic reaction to alcohol, often continue to drink recklessly, or attempt to alleviate food allergy. In fact, allergies can be no relationship between this and was due to alcohol metabolism of acetaldehyde accumulation in the body results.
How the metabolism of alcohol
after drinking, alcohol is absorbed into the blood in the digestive tract, in addition to the amount of less than 10% ethanol prototype is discharged from the lung and kidney, the main metabolism in the liver. Simply put, alcohol, first by alcohol dehydrogenase (ADH) catalyzed metabolism of acetaldehyde. Aldehyde dehydrogenase in acetaldehyde further 2 (ALDH2) into acetic acid under the action of acetic acid and then will participate in multiple metabolic pathways in the body to eventually get CO2 and water, out of the body. Which, in addition to ethanol itself has some toxicity, the most damaging is acetaldehyde, and for many tissues and organs are toxic and may cause DNA damage, is also considered a variety of carcinogenic effects. Even in animal experiments to do with acetaldehyde cancer model mutagen. Can be seen piled up of acetaldehyde if the body, health is very bad. The export is to be ALDH2 acetaldehyde metabolism, so if a problem the role of ALDH2, acetaldehyde is likely to pile up. Other non-specific oxidase, although it can be oxidized to acetaldehyde, but not the efficiency of ALDH2, requiring a longer time. Acetaldehyde in the body longer stay, the greater the damage to the body.
important magic weapon against acetaldehyde is aldehyde dehydrogenase mentioned earlier, 2 (ALDH2). However, there are some people the gene encoding ALDH2 protein deficiencies, making the enzyme glutamate 487 (Glu) by lysine (Lys) instead. Glu allele (ALDH2 * 1) code received is a normal activity of the protein, while the Lys allele (ALDH2 * 2) there is no activity of the encoded protein. Learned in high school biology class, our body cells have two sets of each gene locus gene, may contain different alleles. For ALDH2, if all Lys allele, get the Lys / Lys homozygotes, then no ALDH2 activity. If an allele is Lys, a Glu allele was obtained is Lys / Glu heterozygotes will have low ALDH2 activity, in fact, heterozygous ALDH2 ALDH2 activity is lower than the normal 100 times. Both the gap in the metabolic rate is really big ah.
Study how to say?
different genes, different activity, resulting in health effects of alcohol are also different. Normal people have normal ALDH2, acetaldehyde faster metabolism not easily lead to the accumulation of acetaldehyde, some smaller health hazards. But for the defective gene in human, the situation is further divided into two kinds. ALDH2 Lys / Lys homozygotes, because can not metabolize alcohol, numerous liquor power, and soon passed out, so instead of not going to drink, health, will not have any big impact. But if the ALDH2 Lys / Glu heterozygotes, due to a weak or ALDH2 activity, Through opposition, will gradually on acetaldehyde, blush phenomenon of tolerance has become habitual heavy drinkers.
on drinking, ALDH2 gene defects and the incidence of esophageal cancer between, Philip J. Brooks, and Akira Yokoyama made a detailed study, the paper published in PLoS Medicine on the 2009 [1]. They think that the people who are drinking, ALDH2 Lys487 allele blush and the same time, the high incidence of esophageal cancer has important implications, can only produce ALDH2 Lys / Glu heterozygotes If the person alcohol, it may suffer the risk of esophageal cancer than ALDH2 gene defect were not high. The purpose of this paper is to prompt the doctor can ask the patient is not very easy drinking blush to determine that they are not defective ALDH2 people, and because these patients if I drink, the chance of suffering from esophageal cancer may be higher Therefore, they should be advised to drink less, and increase the inspection aspect of esophageal cancer.
the main target of this study is the population of Japan and Taiwan. A paper in 2010 the situation on the mainland populations studied [2]. Similar conclusion: there is a genetic defect in ALDH2 alcoholics alcoholics than normal risk of suffering from esophageal cancer is higher.
Conclusion: The rumors confirmed. Related genetic research from the known results, the blush is indeed Many people are not drunk on our own to determine which should continue to drink, and some even think that after a period of exercise, amount of alcohol known to be okay. In fact, people who have been through numerous liquor power exercise tolerance of alcohol, but will drink more alcohol, causes the body to accumulate more acetaldehyde, causing more damage. Therefore, people still do not drink alcohol blush is okay or not drink, not just to prevent cancer, diseases are so many.
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